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M3512
Sigma
(±)-Miconazole nitrate salt
| Synonym: | 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole |
| CAS Number: | 22832-87-7 |
| Linear Formula: | C18H14Cl4N2O · HNO3 |
| Molecular Weight: | 479.14 |
| EC Number: | 245-256-6 |
| MDL number: | MFCD00058161 |
| PubChem Substance ID: | 24896848 |
Description
| Biochem/physiol Actions | Antifungal azole. Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, resulting in an altered cell membrane permeability. Also inhibits peroxidases, which results in accumulation of peroxide within the cell.1 |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-43 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | NI4771000 |
References
| Cited Reference | 1. Fothergill, A.W., Miconazole: a historical perspective. Expert Rev. Anti. Infect. Ther. 4, 171-5, (2006) |
| reference | Vanden Bossche, H., et al., Anti-Candida drugs--the biochemical basis for their activity. Crit. Rev. Microbiol 15, 57-72, (1987) |
| Merck | Merck 14,6178 |
